翻訳と辞書 Words near each other ・ Malat ・ MALAT1 ・ MALAT1-associated small cytoplasmic RNA ・ Malatang ・ Malataverne ・ Malate Catholic School ・ Malate Church ・ Malate dehydrogenase ・ Malate dehydrogenase (decarboxylating) ・ Malate dehydrogenase (disambiguation) ・ Malate dehydrogenase (NAD(P)+) ・ Malate dehydrogenase (NADP+) ・ Malate dehydrogenase (oxaloacetate-decarboxylating) ・ Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) ・ Malate dehydrogenase (quinone) ・ Malate dehydrogenase 2 ・ Malate oxidase ・ Malate synthase ・ Malate, Manila ・ Malate-aspartate shuttle ・ Malateh ・ Malatesta ・ Malatesta (film) ・ Malatesta (Rome Metro) ・ Malatesta da Verucchio ・ Malatesta II Baglioni ・ Malatesta II Malatesta ・ Malatesta IV Malatesta ・ Malatesta Malatesta ・ Malatesta Novello Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Malate dehydrogenase 2 ： ウィキペディア英語版 Malate dehydrogenase 2 Malate dehydrogenase, mitochondrial also known as malate dehydrogenase 2 is an enzyme that in humans is encoded by the ''MDH2'' gene. Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4191 )〕 ==Structure== The protein encoded by MDH2 exists as a dimer, which indicate the important connection between protein stability and enzymatic activity. Each subunit contains two structurally and functionally distinct domains. The first is the NAD-binding domain, which exists in the amino-terminal half of each molecule, and contains a parallel-sheet structure, otherwise known as a Rosman fold motif. The core dinucleotide binding structure is composed of four beta-sheets and one alpha-helix. The other domain is a carboxy-terminal domain that contains the substrate binding site and amino acids that are necessary for catalysis. The active site of these enzymes is in a cleft between two domains. Crystallography reveals the dimer interface, which consists mainly of interacting alpha-helices that form a compact interaction. The active sites in these dimeric proteins are well separated from each other. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Malate dehydrogenase 2」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.